Polymer matrix nanocomposites are one of the most important polymeric materials that exhibit very good mechanical and thermal properties. These materials have applications in medical goods. In this paper nanocomposites based on natural rubber and solid epoxy polymeric resin reinforced with nano-sized iron oxide (Fe2O3) nanopatricles are prepared via mechanical blending method. Indeed the melt mixing process by two roll mills are used in this investigation to prepare a well-dispersed nanocomposite samples. In these compounds, dispersion and distribution of nano iron oxide in the natural rubber / solid epoxy resin matrix are investigated. We investigate the morphology of natural rubber / solid epoxy resin/nano iron oxide nanocomposites by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results of morphological observations of present investigation showed that the presence of nano iron oxide has almost been distributed in the natural rubber matrix