Ardalan, Mohammadreza.

Nasri, Hamid.

Rafieian-Kopaei, Mahmoud.

International Journal of Preventive Medicine

PubMed

Hamid Nasri

Mohammad-Reza Ardalan

Mahmoud Rafieian-Kopaei

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Comment on: Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-representative Sample of Iranian Adolescents: The CASPIAN-III Study

shahrekord university of medical scinces

Letters to Editorwww.ijpm.inr1482 International Journal of Preventive Medicine, Vol 5, No 11, November, 2014Comment on: Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-representative Sample of Iranian Adolescents: The CASPIAN-III StudyHamid Nasri, Mohammad-Reza Ardalan1, Mahmoud Rafi eian-Kopaei2DEAR EDITOR,We read with great interest, the published article entitled “relationship of  serum magnesium and Vitamin D levels in a nationally-representative sample of  Iranian adolescents; the CASPIAN-III study” by Kelishadi et al. They aimed, to assess the association of  serum magnesium and Vitamin D (25(OH) D) levels in 330 students, aged range from 10 to 18 years. At this study, they found the significant association of  magnesium with 25(OH) D serum levels. They suggested further considerations to find the underlying mechanisms and the clinical significance of  the current findings.[1] At this study, we would like to point out a few notes. In a cross-sectional investigation on a 41 patients of  end-stage renal failure on regular hemodialysis, we found a significant positive correlation of  serum magnesium with 25 OH Vitamin D (r = 0.40, P = 0.009). This significant association was strongly positive in nondiabetic, diabetic, females, and male groups individually.[2] Recently, Gandhe et al., conducted a study to find out the probable correlation of  Vitamin D3, and magnesium levels in Type II diabetes mellitus cases. They firstly observed low magnesium levels in Type II diabetes mellitus subjects, as compared to healthy controls and secondly, 1Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran, 1Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, 2Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharhekord, IranCorrespondence to:Prof. Mahmoud Rafi eian-Kopaei,Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharhekord, Iran. E-mail: rafi eian@yahoo.comDate of Submission: Mar 07, 2014Date of Acceptance: Jul 12, 2014How to cite this article: Nasri H, Ardalan MR, Rafi eian-Kopaei M. Comment on: Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-representative Sample of Iranian Adolescents: The CASPIAN-III Study. Int J Prev Med 2014;5:1482-3.they detected a positive association of  Vitamin D with magnesium levels (r = 0.92, P < 0.01). They concluded that, Vitamin D levels can also influence the magnesium status. They additionally found the negative association of  magnesium with insulin resistance.[3] Hence, hypomagnesemia may leads to increased insulin resistance and as well established the fact that, low magnesium status, affects glucose metabolism too.[3-7] Fibroblast growth factor-23 is associated with atherosclerosis and cardiovascular mortality in chronic kidney disease patients and healthy subjects.[8-11] It was found that, magnesium deficiency increases serum fibroblast growth factor 23 levels too.[12] Thus, the positive association of  magnesium deficiency and fibroblast growth factor 23 increment,[1,12-16] further imply the significance of  magnesium deficiency and Vitamin D, while Vitamin D has a role in magnesium metabolism.[17] This finding is especially important in the pediatric group that elegantly detected by Kelishadi et al. Paper of  Kelishadi et al., also had another message to further pay attention to fortified the micronutrients to the pediatrics, as a possible prevention of  progression of  renal failure in the pediatric population at risk too.Nasri, et al.: Comment on: Relationship of serum magnesium and Vitamin D 1483International Journal of Preventive Medicine, Vol 5, No 11, November, 2014R EFERENCES1. Kelishadi R, Ataei E, Ardalan G, Nazemian M, Tajadini M, Heshmat R, et al. Relationship of Serum Magnesium and Vitamin D Levels in a Nationally-Representative Sample of Iranian Adolescents: The CASPIAN-III Study. Int J Prev Med 2014;5:99-103.2. Baradaran A, Nasri H. Correlation of serum magnesium with serum parathormone levels in patients on regular hemodialysis. Saudi J Kidney Dis Transpl 2006;17:344-50.3. Gandhe MB, Jain K, Gandhe SM. Evaluation of 25(OH) Vitamin D3 with Reference to Magnesium Status and Insulin Resistance in T2DM. J Clin Diagn Res 2013;7:2438-41.4. Nasri H, Rafi eian-Kopaei M. Signifi cant difference of serum 25-hydroxyvitamin D level in male hemodialysis patients with our without diabetes; a single center study. J Nephropharmacol 2012;1:3-4.5. Ghorbani A, Baradaran A. Magnesium and diabetes mellitus. J Renal Inj Prev 2012;1:46-7.6. Nasri H. Impact of diabetes mellitus on parathyroid hormone in hemodialysis patients. J Parathyr Dis 2013;1:9-11.7. Baradaran A. Beyond mineral metabolism, the bright immunomodulatory effect of vitamin D in renal disease. J Nephropharmacol 2012;1:17-8.8. Asicioglu E, Kahveci A, Arikan H, Koc M, Tuglular S, Ozener C. Fibroblast growth factor-23 levels are associated with uric Acid but not carotid intima media thickness in renal transplant recipients. Transplant Proc 2014;46:180-3.9. Nasri H, Sahinfard N, Rafi eian M, Rafi eian S, Shirzad M, Rafi eian-kopaei M. Effects of Allium sativum on liver enzymes and atherosclerotic risk factors. J Herb Med Pharmacol 2013;2:23-8.10. Roshan B, Stanton RC. A story of microalbuminuria and diabetic nephropathy. J Nephropathol 2013;2:234-40.11. Behradmanesh S, Nasri H. Association of serum calcium with level of blood pressure in type 2 diabetic patients. J Nephropathol 2013;2:254-7.12. Matsuzaki H, Kajita Y, Miwa M. Magnesium defi ciency increases serum fi broblast growth factor-23 levels in rats. Magnes Res 2013;26:18-23.13. Nasri H. Impact of diabetes mellitus on parathyroid hormone in hemodialysis patients. J Parathyr Dis 2013;2:1-2.14. Hernandez GT, Nasri H. World kidney day 2014: Increasing awareness of chronic kidney disease and aging. J Renal Inj Prev 2014;3:3-4.15. Hajivandi A, Amiri M. World kidney day 2014: Kidney disease and elderly. J Parathyr Dis 2014;2:5-6.16. Rafieian-Kopaei M, Nasri H. Vitamin D therapy in diabetic kidney disease. J Nephropharmacol 2014;3:3-4.17. Baradaran A. Primary hyperparathyroidism and kidney; recent fi ndings. J Parathyr Dis 2014;2:7-10.Source of Support: Nil, Confl ict of Interest: None declared.

Comment on: Relationship of serum magnesium and vitamin D levels in a nationally-representative sample of Iranian adolescents: The CASPIAN-III study

Comment on: Relationship of serum magnesium and vitamin D levels in a nationally-representative sample of Iranian adolescents: The CASPIAN-III study

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