Negative predictive value (NPV) is one of the important indicatives for evaluating a medical procedure. Herein, we have evaluated the NPV of 16-multidetector-row CT angiography (CTA) in comparison with conventional invasive angiography (CIA) in the diagnosis of significant stenosis. In this regard, 8 patients suspected to stenosis were investigated. They patients were undertaken CIA procedure after CTA. The obtained results show, the NPV of 50 for patient-base analysis. The findings of this study reveal that CT angiography with 16-slice scanner might be considered as an acceptable technique for rapid triage of patients. Low values of NPV reveal a moderate performance of CTA. However, due to low number of patients, the obtained results cannot be used for final decision. Hence, more is required to improve and achieve reliable results