Rafieian-Kopaei, M.

Iranian Red Crescent Medical Journal

PubMed

shahrekord university of medical scinces

Iran Red Crescent Med J. 2014 June; 16(6): e10264. DOI: 10.5812/ircmj.10264Published online 2014 June 5. LetterIn Vitro Evaluation of Antioxidant Properties of Ten Iranian Medicinal PlantsMahmoud Rafieian-Kopaei 1,*1Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, IR Iran*Corresponding Author: Mahmoud Rafieian-Kopaei, Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, IR Iran. Tel: +98-9131811842, Fax: +98-3813330709, E-mail: rafieian@yahoo.com Received: January 13, 2013; Revised: August 5, 2013; Accepted: March 15, 2014Keywords:Antioxidant; Evaluation; Plants, MedicinalCopyright © 2014, Iranian Red Crescent Medical Journal; Published by Kowsar Corp. This is an open-access article distributed under the terms of the Creative Com-mons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Dear Editor,    We read with interest the recently published article in the esteemed Iranian Red Crescent Medical Journal, by Moein et al., entitled “In vitro antioxidant properties evaluation of 10 Iranian medicinal plants by different methods”(1) in which antioxidant properties of ten Ira-nian medicinal plants were evaluated with two reliable models. The authors found very high levels of phenolic compounds and antioxidant activities in Verbascum sinu-atum L. and Rosa damascena Mill so that the antioxidant activities in terms of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging model in V. sinuatum L. (IC50 = 263.52 ± 5.981 μg/mL) and R. damascena Mill (IC50 = 287.9 ± 5.675 μg/mL) were even higher than gallic acid (IC50 = 25.32 ± 5.593 μg/mL), which is usually used as a standard antioxidant. The authors have skipped from these valuable results that might have tremendous clinical implications. Most of the untreatable diseases or toxic effects of drugs are related to free radicals and consumption of antioxidants may scavenge these free radicals. It is being increasingly recognized that many of currently untreatable or hard to treat diseases are due to the "oxidative stress". Oxida-tive stress is initiated by free radicals and results from an imbalance between formation and neutralization of these highly active compounds. Free radicals seek stabil-ity through electron pairing with biological macromole-cules such as lipids, proteins, and DNA in healthy human cells and cause lipid peroxidation along with protein and DNA damage. These changes highly contribute to the atherosclerosis, cardiovascular diseases, cancer, ageing, and inflammatory diseases (2-5). Human cells protect themselves against free radical damage by antioxidant compounds such as ascorbic acid, tocopherol, and glu-tathione or enzymes such as catalase and superoxide dismutase (6-8). These protective mechanisms might be disrupted by various pathological processes. In these situations, antioxidant supplements are vital to com-bat oxidative damage (6-8). Recently, high attention has been directed towards the ethnomedicines with strong antioxidant properties but low toxicities. Although, in Moein et al. article, (1) the extracts were not examined for different reactive oxygen species such as “singlet oxy-gen, superoxide, hydrogen peroxide, hydroxyl, nitric ox-ide and peroxynitrite”, total antioxidant activities were examined and showed to be very high for V. sinuatum L. and R. damascena Mill. Plants with antioxidant activities have shown promising results in various conditions in-cluding prevention or treatment of hyperlipidemia (9), diabetes (10), cancer (11), ischemia, and inflammatory dis-eases (4). These plants have also protective effects against toxicity of different drugs (12-15). Therefore, the plants V. sinuatum L. and R. damascena Mill, which have high lev-els of antioxidants, are promising and worth examining for the conditions that cause extensive damage to tissues and biomolecules leading to various disease conditions, especially degenerative diseases and lysis degeneration.References1.       Moein S, Moein M, Khoshnoud MJ, Kalanteri T. In vitro antioxi-dant properties evaluation of 10 Iranian medicinal plants by dif-ferent methods. Iran Red Crescent Med J. 2012;14(12):771–5.2.       Behradmanesh S, Derees F, Rafieian-kopaei M. Effect of Salvia of-ficinalis on diabetic patients. J Ren Inj Prev. 2013;2(2):57–9.3.       Tavafi M. Protection of renal tubules against gentamicin induced nephrotoxicity. J Ren Inj Prev. 2012;2(1):5–6.4.       Maxwell SR. Prospects for the use of antioxidant therapies. Drugs. 1995;49(3):345–61.5.       Rafieian-Kopaie M, Baradaran A. Teucrium polium and kidney. J Ren Inj Prev. 2013;2(1):3–4.6.       Niki E, Shimaski H, Mino M. Antioxidantism-free radical and bio-logical defense. Gakkai Syuppn Center. 1994:3–16.7.       Nasri H. On the occasion of the world diabetes day 2013; diabetes education and prevention; a nephrology point of view. J Ren Inj Prev. 2013;2(2):31–2.8.       Tavafi M. Diabetic nephropathy and antioxidants. J Nephropathol. 2013;2(1):20–7.9.       Khajehdehi P. Turmeric: Reemerging of a neglected Asian tradi-tional remedy. J Nephropathol. 2012;1(1):17–22.10.       Rafieian-Kopaei M, Baradaran A. Teucrium polium and kidney. J Ren Inj Prev. 2012;2(1):3–4.11.       Shirzad H, Taji F, Rafieian-Kopaei M. Correlation between anti-oxidant activity of garlic extracts and WEHI-164 fibrosarcoma Rafieian-Kopaei M Iran Red Crescent Med J. 2014;16(6):e102642tumor growth in BALB/c mice. J Med Food. 2011;14(9):969–74.12.       Shirzad H, Shahrani M, Rafieian-Kopaei M. Comparison of mor-phine and tramadol effects on phagocytic activity of mice perito-neal phagocytes in vivo. Int Immunopharmacol. 2009;9(7-8):968–70.13.       Rafieian-Kopaei M, Nasri H. Ginger and diabetic nephropathy. J Ren Inj Prev. 2012;2(1):9–10.14.       Rafieian-Kopaei M, Baradaran A, Rafieian M. Plants antioxidants: From laboratory to clinic. J Nephropathol. 2013;2(2):152–3.15.       Nasri M H, Rafieian-Kopaie. Silymarin and Kidney.. J Ren Inj Prev. 2012;1(1):3–6.

In Vitro Evaluation of Antioxidant Properties of Ten Iranian Medicinal Plants

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