Resembling most other techniques for medical imaging, ultrasound (US) changed radically that have ameliorate its spatial and temporal resolution, provided three-dimensional data, and permitted evaluation of dynamic physiologic processes similar to blood flow or tissue motion. The possibility of targeting US conflict agents to disease-related markers and for non-invasively evaluating the molecular profile of disease in animal models was strongly established. The technique is now being applied as a high-Throughput research tool that can define pathophysiological processes in both the spatial and temporal domains. Early steps are presently under achievement in the direction of the advance of targeted agents appropriate for clinical use of this useful method