Efficiency of treatment with vitamin D on biochemical indexes, lipid profile, and fatty liver indexes in type 2 diabetic patients with vitamin D deficiency and nonalcoholic fatty liver
Prevalence of metabolic syndrome, type 2 diabetes, and non alcoholic fatty liver has been recently on rise in worldwide. This study was conducted to explore the association between vitamin D deficiency and incidence of fatty liver disease in type 2 diabetes patients and also to examine the efficacy of treatment with vitamin D in type 2 diabetes patients with vitamin D deficiency and non alcoholic fatty liver referring a specialty clinic in Shahrekord. In the first step (cross-sectional phase) of this two-step study, 108 patients with type 2 diabetes were examined for vitamin D level, biochemical indexes, lipid profile, and fatty liver indexes. In the second step (clinical trial phase), individuals with nonalcoholic fatty liver and vitamin D deficiency as treatment group underwent treatment with 50000 vitamin D units a week for 12 weeks. 3.96% of patients had fatty liver and 1.61% of patients had vitamin D deficiency of different severities. There was no significant association found between vitamin D deficiency and presence or severity of nonalcoholic fatty liver in patients (P > 0.05). Treatment with vitamin D had no significant effect on biochemical indices, liver function, fasting blood sugar, and hemoglobin A1c (P > 0.05), but serum level of cholesterol and low density lipoprotein (LDL) decreased in treatment patients compared to control group (P < 0.001). No significant association was found between vitamin D deficiency and presence or severity of nonalcoholic fatty liver; but treatment of type 2 diabetes patients with vitamin D supplementation decreased the serum level of cholesterol and LDL
