Effect of oral Aluminum intake on sex hormones of rat

Abstract

History and Objectives: Aluminum absorbed through several means and its increased absorption is associated with some complications. Aluminum may alter and complicate the function of calcium and its biological effects leading to the sex hormone changes. Its absorption competes with Iron and may cause anemia. The present study is carried out to determine the effect of prescribed oral aluminum on the sex hormone changes of rat. Materials and Methods: An experimental study was performed on 52, 6 months old rat with average weight of 318 grams. Rats were divided into 4 groups of 13. One group was taken as control and 3 others were experimental groups. Experimental groups were given 0.625, 1.25 and 2.5 mg of aluminum in each meal for 60 days. The effect of aluminum intake was studied on the blood hemoglobin, hematocrit, LH, FSH and testosterone levels. T-test and analysis variance were performed. Results: Blood hemoglobin levels were 14.93±0.27, 13.24±0.27 and 11.84±0.35 for control and 1.25 and 2.5 mg experimental groups respectively (P<0.001). Hematocrit levels were 42±0.36% and 40±1 for control and 2.5mg experimental group respectively (P<0.001). FSH levels in 2.5mg experimental group and LH and testosterone levels in 2.5 and 1.5 mg experimental groups had less significant difference compared to the control group (P<0.05). No significant difference was observed with other groups. Conclusion: Increased aluminum intake in male rats induces anemia and decreases level of sex hormones