Mirsane, S.

kashan university of medical sciences

 Caspian J Intern Med 2017; 8(3):226-227 
226                                                                               Mirsane SA, et al. 
Caspian J Intern Med 2017; 8(2):226-227 
DOI: 10.22088/cjim.8.3.226 
Letter to Editor 
 
Benefits of ellagic acid from grapes and pomegranates against colorectal cancer 
 
Dear Editor, 
We read an interesting article entitled: “Cytokeratin7 
expression in gastric and colorectal adenocarcinoma: 
Correlation with prognostic factors” in the Caspian Journal 
of Internal Medicine, 2015: 6 (4). We admire the authors of 
above paper for their valuable paper. In this article, it has 
been explained that in Iran, gastric and colorectal 
adenocarcinoma are the second and the fifth most common 
cancers respectively. It is then suggested to increase attention 
to prevention of colorectal cancer which is very important. 
On the other hand, almost all people consume fruits as the 
best and safest way to treatment and elimination of diseases. 
Fruits such as pomegranates and grapes have remedial 
purposes. It is worth noting that the foods that introduced in 
the Holy Qur'an as good and useful foodstuffs, have many 
beneficial effects on health human and even they have more 
effective spiritual effects on humans’ life. According to the  
Holy Qur'an, pomegranate and grape grow in the gardens of 
paradise (1-3). 
Cancer develops when cells in the human body begin to 
grow out of control and crowd out normal cells (4). Certainly 
cancers are very dangerous, so attention to reduction and 
treatment is necessary especially colorectal cancer (CRC). 
Our goal is to evaluate the benefits of ellagic acid from 
pomegranates and grapes in CRC. Fruits and vegetables have 
been said to have a strong protective effect against CRC 
especially those with ellagic acid. The highest levels of 
ellagic acid are found in pomegranates and grapes. The 
anticarcinogenic effects of ellagic acid has been detected. 
Also, ellagic acid has an anti-inflammatory role in the 
treatment of chronic ulcerative colitis as to prevent the 
development of colon cancer (5-8).  
Scholars also suggested that ellagic acid is an efficient 
multiple-function protector against oxidative stress (9). Kao 
et al. have reported the anti-proliferative effects of ellagic 
acid on different CRC cell types (10). It should be noted that 
the pathway of PI3K/Akt plays a central role in tumor 
genesis in colon (11, 12) and ellagic acid can inhibit 
chemically-induced colorectal tumorigenesis via mechanism 
involving the inhibition of Akt phosphorylation at Ser473.  
 
Similarly, the inhibitory impact of ellagic acid on Akt 
phosphorylation (at Thr308 and Ser473) has been observed 
in another study (13, 14). Researchers have stated that ellagic 
acid and its metabolites can inhibit CaCo-2 (the Caco-2 cell 
line is a continuous cell of heterogeneous human epithelial 
colorectal adenocarcinoma cell) proliferation through cell  
cycle arrest (15). We conclude that grape and pomegranate 
juice consumption has remedial and preventive impacts in 
CRC. We recommend that further studies should be 
conducted to obtain the other benefits of ellagic acid and use 
the significant advantages in studies of intestinal health 
promoting properties and decrease rates of CRC. 
 
Keywords: Grapes, pomegranates, colorectal cancer, gastric, 
ellagic acid  
Citation: 
Mirsane SA, Mirsane SM. Benefits of ellagic acid from grapes and 
pomegranates against colorectal cancer. Caspian J Intern Med 2017; 
8(3):133-134. 
 
Sayedalireza Mirsane (BSc) 1* 
Sayedmojtaba Mirsane (BSc) 2 
 
1. School of Nursing and Midwifery, Kashan University of Medical 
Sciences, Kashan, Iran. 
2. Department of Education, Khansar, Isfahan, Iran. 
 
Correspondence 
Sayedalireza  Mirsane, School of Nursing and Midwifery, Kashan 
University of Medical Sciences, Kashan, Iran. 
 
Email: alireza.seyed70@gmail.com 
Tel: 0098 3157232469 
Fax: 0098 3157232469  
 
Received: 18 Aug 2016 
Revised: 10 Dec 2016 
Accepted: 4 Jan 2017  
 
 Caspian J Intern Med 2017; 8(3): 226-227 
Ellagic acid and colorectal cancer                                                                        227 
 
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Benefits of ellagic acid from grapes and pomegranates against colorectal cancer

http://eprints.kaums.ac.ir/2701/1/Benefits%20of%20ellagic%20acid%20from%20grapes%20and%20pomegranates%20against%20colorectal%20cancer.pdf

Benefits of ellagic acid from grapes and pomegranates against colorectal cancer

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