Background and Objective: Premenstrual syndrome (PMS) refers to a range of physical and psychological symptoms which regularly occur during the luteal phase of a menstrual cycle and disappear short after menstruation starts. Considering the negative effects of PMS on women's daily life, various treatments have been developed to alleviate its symptoms. Vitamin B6 is one of the complementary therapies used to treat PMS. The present meta-Analysis aimed to investigate the effects of vitamin B6 on PMS. Methodology: Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were searched to identify studies addressing the effects of vitamin B6 on PMS. The relevant data obtained from these papers were analyzed by a random-effects model. Data were analyzed using R Ver. 3.2.3 Software and STATA. Results: There were significant reductions in the mean scores of PMS after treatment with vitamin B6 compare to control groups. Moreover, the mean PMS scores of the two groups were also significantly different after the treatment. The mean difference between the two groups was -1.19 [95% CI: -1.94,-0.44; P = 0.002]. Significant reductions were also observed in physical symptoms (P = 0.006) and psychological symptoms (P < 0.001) of PMS after the intervention. Conclusion: The results of our meta-Analysis confirmed vitamin B6 as a beneficial, inexpensive, and effective treatment for PMS symptoms. Therefore, the administration of this treatment option will enable midwives to achieve the important goal of reducing PMS symptoms
