Background: The traditional classification of dermatologic diseases is based on etiology and clinical appearance, however, regional approach could be an appropriate alternatrive in clinical or research affairs. The present study was conducted in a dermatologic clinic in Razi hospital, Tehran to determine the frequency of cutaneous lesions of groin area and proposed the importance of a regional approach.Materials and methods : This cross sectional study was performed on 3401 patients referring consecutively. Diagnosis was made by clinical and paraclinical studies, if necessary biopsy was also taken. Meanwhile, sex, age and body mass index were all recorded. Results: Of 3401 patients, 3.9 had cutaneous lesions of groin area. Dermatophytosis, erythrasma, and seborrheic dermatitis were reported in 17.2, 14.9, and 14.9 of individuals. Lesions had shown significant differences according to the sex, and type of lesions.Conclusion : Cutaneous lesions of groin area are relatively common. Further regional approach studies are strongly recommended