Aims: Air is the combination of atmospheric components or physical conditions of the current atmosphere in a certain place and a certain time. The aim of this study was to assess the relationship between weather components, air atmospheric pollutants and the number of individuals that were hospitalized due to cardiovascular diseases in polluted days. Instrument & Methods: In this descriptive study during 2010 to 2013, the weather parameters in ground and upper levels of Isfahan City, Iran, weather stations were studied and air quality data were collected from 11 different points of the city. The number of cardiovascular patient that were hospitalized was determined by collecting the data of medical record department of 3 hospitals of Isfahan City, Iran; Shahid Chamran, Al-Zahra, and Ali-Asghar. Data were analyzed by SPSS 19 software using Pearson correlation. Findings: There were significant correlations between the number of hospitalizations and minimum temperature (r=0.943; p=0.0001), maximum temperature (r=0.973; p=0.0001), average temperature (r=-0.069; p=0.013), rainfall (r=-0.326; p=0.0001), humidity (r=-0.326; p=0.0001), air pressure (r=0.257; p=0.0001), and wind speed (r=-0.011; p=0.021). There was a significant difference between the average numbers of hospitalizations due to cardiovascular diseases according to the range of AQI. Regarding the air pollutant parameters, the only significant relation was observed for PM10 (p=0.004) and other factors showed no significant relation (p<0.05) to the numbers of hospitalizations. Conclusion: The number of hospitalizations due to cardiovascular diseases is just affected by the PM10 factor of air pollution
