Molecular characterization of PCa and BPH using the angiogenic tissue markers CD31 and CD45 to
differentiate between the two major types of prostate gland disorders is investigated. 8 clinically
characterized biopsies were analyzed at the Histopathology Laboratory of the Ekiti State University
Teaching Hospital; the tissue sections were processed for antigen retrieval and were labeled with antiCD45 and anti-CD31 to map the location of angiogenic cells and vascularization in BPH and PCa. The
results showed that PCa biopsies expressed embryonic stem cell status of CD31+/CD45+, while BPH
showed CD31-/CD45+. This suggests the presence of migrating blood cells (vascularization) in PCa and
the absence of such in BPH. It also confirms the role of platelets in endothelial activation that can result
to cell proliferation and apoptosis in the prostate gland of either BPH or PCa diagnosed patients
