'Columbia University Libraries/Information Services'
Doi
Abstract
A theoretical calculation involving minimization of energy functions was made to determine the conformation of a deoxydinucleoside monophosphate pyrimidine[ ]pyrimidine cis-syn cyclobutane dimer. Such single-stranded moieties are useful models for the in uiuo situation because single strands are more easily damaged, and the damage inhibits the normal function of single-stranded replicating DNA. The calculated minimum-energy conformer was incorporated in a mode l of B-DNA to assess the influence of this covalent lesion on the normal form of DNA
