Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Abstract
Dissertation presented to obtain the Ph.D degree in Biochemistry, Structural BiochemistryHaloacid dehalogenase (HAD) superfamily (CL0137), includes a
diverse range of enzymes that use an aspartate carboxylate as
nucleophile (Aravind et al., 1998; Koonin and Tatusov, 1994). There
are ~79000 sequences classified into this superfamily in Pfam
database and even more sequences, 148000, classified as HAD-like in
the UniProt database (as of 19th February 2013).(...
