Formal [3+2] Cycloaddition Reactions of Electron-Rich Aryl Epoxides with Alkenes under Lewis Acid Catalysis Affording Tetrasubstituted Tetrahydrofurans
We report on the regio- and stereoselective synthesis of tetrahydrofurans by reaction
between epoxides and alkenes in the presence of a Lewis acid. This is an unprecedented formal [3+2]
cycloaddition reaction between an epoxide and an alkene. The chemical reaction represents a very
concise synthesis of tetrahydrofurans from accessible starting compounds