Con el objetivo de determinar la efectividad de la planta Petiveria alliacea (mapurite) sobre la evoluci\uf3n del melanoma maligno (mortalidad, peso corporal y volumen del melanoma) en ratones C57BL/6, 64 ratones fueron distribuidos en tres grupos: control melanoma (10 hembras y 10 machos), Tratamiento Preventivo (10 hembras y 11 machos) y Tratamiento Curativo (12 hembras y 11 machos). Cada individuo se inocul\uf3 con 100.000 c\ue9lulas melanoc\uedticas v\ueda subcut\ue1nea en la superficie plantar. La infusi\uf3n fue preparada al 1% y se administr\uf3 ad libitum; al grupo Preventivo 15 d\uedas previos y al grupo Curativo al momento de la inoculaci\uf3n. Los resultados mostraron, para las hembras una supervivencia significativamente mayor en los grupos tratados, mientras que en los machos no se observ\uf3 diferencias para la supervivencia media, sin embargo, el 20% de los individuos del grupo Tratamiento Preventivo sobrevivi\uf3 m\ue1s de 60 d\uedas. En cuanto al peso, en los machos el 100% de los individuos del grupo Control perdieron peso, mientras que en los grupos tratados el 64% del grupo preventivo y el 55% del grupo Curativo perdieron peso, siendo la diferencia estad\uedsticamente significativa. Tanto en las hembras como en los machos el tumor creci\uf3 significativamente, sin embargo, en el grupo Preventivo de machos hubo un menor crecimiento tumoral para las semana 3 y 4 con tendencia a la significancia. En conclusi\uf3n la infusi\uf3n de mapurite aumenta la supervivencia, disminuye la p\ue9rdida de peso y el crecimiento tumoral, lo cual sugiere que podr\ueda ser utilizado como coadyuvante en el tratamiento del melanoma maligno.
Palabras clave: Petiveria alliacea, ratones C57BL/6, c\ue9lulas melanoc\uedticas, c\ue1ncer, mapurite.
ABSTRACT
The present work is defined as a descriptive study supported by non experimental field research, whose With the aim to determine the effectiveness of the P. alliacea (mapurite) plant infusion on the evolution of malignant melanoma in C57BL/6 mice, 64 mice were distributed in three groups: Control Melanoma, Preventive Treatment and Curative Treatment. 100,000 melanocytic cells were inoculated subcutaneous in the paw pad. Mapurite infusion was prepared at 1% and administered ad libitum, starting 15 days prior to inoculation in the Preventive and at the moment of inoculation in the curative group. Results shown that females survival was significantly higher in the groups treated with P. alliacea. In males no statistically significant differences were observed for mean survival time, however, 20% of the Preventive group survived more than 60 days. In terms of weight, statistically significant differences between groups were obtained in males, where 100% of those in the Control group, 64% in the Preventive group and 55% in the Curative group lost weight. In both females and males, the tumor increased significantly, however, in the male Preventive group, tumors were smaller at the third and fourth weeks, with a statistically tendency to significance. In conclusion, P. alliacea infusion increased survival and decreased lost weight and tumor growth, which suggest that mapurite could be used as an adjuvant in the treatment of malignant melanoma.
Key words: P. alliacea, mice C57BL/6, melanotic cells, cancer, mapurite. <br
