The aim of this study was to analyze the influence of discrimination perception in the quality of life and mental and physical health of Brazilian women living in Portugal, drawing on a descriptive research with a quantitative approach, with 682 female immigrants. Data collection was carried out in two modalities: online, using the LimeSurvey Platform; and presential, conducted at the Associação Mais Brasil [Association More Brazil] and at the Consulate-General of Brazil in Porto and Lisbon, with the application of the Perception of Discrimination Scale and the Medical Outcomes Study 36 – Item Short – Form Health Survey (SF -36). A significant negative correlation was observed between most SF-36 items and the Perception of Discrimination Scale, demonstrating an inversely proportional relation when respondents reporting a higher level of discrimination presented a lower quality of life. Results demonstrate the presence of a strong perception of discrimination, turning it into one of the greatest problems faced by immigrants. Among the most significantly affected dimensions, the following aspects stand out: emotional, pain, overall health status, vitality, social aspects, perception of discrimination, and health changes through time. The exception lies in the functional capacity dimension, which does not present a significant relation with the Perception of Discrimination Scale. The outcomes highlight the negative impact of perceived discrimination on the quality of life dimensions, engendering harmful effects, as well as on physical and mental health. The study points out the need to create public policies that seek to receive, include and integrate female immigrants, guaranteeing their rights and providing information on their duties, in order to reduce discrimination and improve the quality of life and health of this population.info:eu-repo/semantics/publishedVersio