This study examines the role of spatial configuration in shaping patterns of immigrant segregation through the case study of Gerani, Athens. Previous research has suggested that despite its negative effects, segregation can be positive as a key mode of accommodating urban diversity. In this context, this study asks what is the role of space in shaping immigrant segregation patterns and accommodating difference. Although Greece has accepted major migration waves during the last decades, the Greek state is characterised by the lack of internal policies towards immigrants’ integration, leading to social friction. The district of Gerani reflects the current socioeconomic and spatial transformations of the Greek capital and is chosen for this study as a multi-ethnic district and the most distinct commercial immigrant centre of Athens. The existence of a certain degree of informality that characterises both the built environment and the local economic activities reveal the structure of spontaneous socioeconomic patterns. After establishing the spatial properties of the area through space syntax analysis, the immigrant networks are mapped through primary ethnographic research tracking the development of immigrant economic activities. Finally, the above analyses are combined qualitatively and quantitatively, through statistical analysis. The study suggests that Gerani’s spatial configuration might be related to its consistent deprivation and, consequently, to the concentration of high immigrant densities. Furthermore, despite the supposed homogeneity of the “ghetto” of Gerani, the various ethnic groups appear clustered in the area in terms of economic activities and use of the public realm, while an internal hierarchical rationale emerges; locations characterised by higher levels of “natural movement” and proximity to attractors have clusters of those immigrants who have achieved greater social integration with Greek society, whilst locations with lowers levels of “natural movement” and adjacent to abandoned enclaves of anomy have concentrations of the more socially disadvantaged groups. Overall, the issue of immigrant integration and segregation remains mainly a political issue that premises the adoption of long term external and internal policies. Considering, however, the role of spatial design in this process, the current study proposes that specific spatial structures offer immigrants the necessary protection to gradually build their socioeconomic life. These principles should be re-interpreted and assimilated in strategic design proposals and policies that aim at the creation of more socially inclusive solutions