Multiple instance learning is a challenging task in supervised learning and data mining. How-
ever, algorithm performance becomes slow when learning from large-scale and high-dimensional data sets.
Graphics processing units (GPUs) are being used for reducing computing time of algorithms. This paper
presents an implementation of the G3P-MI algorithm on GPUs for solving multiple instance problems
using classification rules. The GPU model proposed is distributable to multiple GPUs, seeking for its scal-
ability across large-scale and high-dimensional data sets. The proposal is compared to the multi-threaded
CPU algorithm with SSE parallelism over a series of data sets. Experimental results report that the com-
putation time can be significantly reduced and its scalability improved. Specifically, an speedup of up
to 149× can be achieved over the multi-threaded CPU algorithm when using four GPUs, and the rules
interpreter achieves great efficiency and runs over 108 billion Genetic Programming operations per second
