Black cumin (Nigella sativa Linn.) seed oil has been known for possessing anticancer activity, with thymoquinone as the active ingredient. Previously reported data show that anticancer activity of thymoquinone is relatively low. In this research, we modify black cumin seed oil with self nanoemulsifying drug delivery system (SNEDDS) formula, so it\u27s effectivity as anticancer can be improved. SNEDDS increases solubility of thymoquinonone and improves its delivery to cancer cells. We used oleic acid as oil phase, tween 80 as surfactan, and propilenglycol as cosurfactan. The steps in this research were determination of upper limit and lower limit of each components, optimization of SNEDDS formula using DX 9 system, equation validation obtained from DX 9, and characterization of SNEDDS based on its size, zeta potensial, thermodynamic stability, and thermodynamic transmitans.
Key words: black cumin seeds oil, characterization, SNEDDS
