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Design and characterization of a biocompatible physical hydrogel based on scleroglucan for topical drug delivery
Authors
Alessandra Adrover
Maria Antonietta Casadei
+6 more
Martina Nardoni
Elisa Ogliani
Settimio Pacelli
Patrizia Paolicelli
Stefania Petralito
Gabriele Varani
Publication date
1 January 2017
Publisher
'Elsevier BV'
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Cite
Abstract
Physical hydrogels of a high-carboxymethylated derivative of scleroglucan (Scl-CM300) were investigated as potential systems for topical drug delivery using three different therapeutic molecules (fluconazole, diclofenac and betamethasone). Rheological tests were carried out on drug-loaded hydrogels along with in-vitro release studies in a vertical Franz cell, in order to investigate if and how different drugs may influence the rheological and release properties of Scl-CM300 hydrogels. Experimental results and theoretical modeling highlighted that, in the absence of drug/polymer interactions (as for fluconazole and betamethasone) Scl-CM300 matrices offer negligible resistance to drug diffusion and a Fickian transport model can be adopted to estimate the effective diffusion coefficient in the swollen hydrogel. The presence of weak drug/hydrogel chemical bonds (as for diclofenac), confirmed by frequency sweep tests, slow down the drug release kinetics and a non-Fickian two-phase transport model has to be adopted. In-vivo experiments on rabbits evidenced optimal skin tolerability of Scl-CM300 hydrogels after topical application. © 2017 Elsevier Lt
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Last time updated on 29/11/2017