: The Effect of Technology Readiness toward Acceptance of Computer Technology on SMEs in Yogyakarta. This research aims to explore the effect of technology readiness to the perceived of usefulness of system and perceived ease of use of the system and the influence of both perceptions of these technologies to the behavioral intention of computer technology in business processes in SMEs in Yogyakarta. The research sample number of 498 SMEs were registered in Disperindagkop Yogyakarta. The sampling technique using simple random sampling technique. The data were obtained using a questionnaire. Data analysis and hypothesis testing using a model of the Partial-Least-Square (PLS). The research found that there are significant technology readiness to the perception of the benefit system and perceived ease of use of the system, and there are significant technological benefit perception and perceived ease of use of technology on interest using computer technology in helping the business processes in SMEs in Yogyakarta