: Quantitative analysis subjects requires knowledge and problem solving skills of pre-service chemistry teachers. The aims of this study was to develop and to analyze problem solving skills in quantitative analysis of preservice teachers through Problem Solving Based Lecture with Group Investigation (PSBL-GI). The study was quasy experiment conducted to pre-service teachers of year 2010 in semester three of Chemistry Education programs in one of LPTK in Central Sulawesi that is one experiment class (PBPS-IK) and one control class (concept and practice approach). Data were then collected on using a test problem solving skills with a reliability coefficient of 0.84. The collected data were analyzed qualitatively and tested the difference between N-gain of problem solving PSBL-GI class with control class at level of significance is 5%. The results showed PSBL-GI can develop pre-service teachers\u27 problem solving skill with categories medium (0,56).The ability to solve problem of pre-service teacher of PSBL-GI class have is greater than the control class. Problem solving skill of high group is better than medium and low groups. The highest N-gain of indicator of problem solving skill is representation (0.82) and the lowest is identification (0,28) while the highest sub subject of quantitative analysis is neutralization titration (0,67) and the lowest is complexometry titration (0,34)