Phyllantus niruri (L) of Euphorbiaceae has stimulator effect. Katuk and meniran plants are the family of Euphorbiaceae so that it is possible to contain similiar coumpound. Katuk leaf contain flavonoid compound it is likely to have imunostimulator. The study was to determine if the ethanol extract of katuk leaf (Sauropus androgynus (L) Merr) has the imunostimulator towards macrophage activites. This is an experimental research used 2-3 month male mice of Swiss type with 20-30 g. They were diveded into six groups and given ethanol extract of katuk leaf with certain dosages 35 mg/kg BB, 70 mg/kg BB, 140 mg/kg BB, levamisol 2.5 mg/kg BB, stimuno 9.1 mg/kg BB and negative control of Na CMC 1% in seven days. On the 8th day, they were infected intraperitoneally by giving 105 Staphylococus aureus bacteria. From 100 cel macrophage cell which latex was phagocytosis on dosage 35 mg/kg BB (37.00), dosage 70 mg/kg BB (44.00), dosage 140 mg/kg BB (49.67), stimuno 9.1 mg/kg BB (57.67), levamisol 2.5 mg/kg BB ( 62.00). The result from 100 cell of latex which was phagocyt dosage 35 mg/kg BB (73.00), dosage 70 mg/kg BB (78.00), 140 mg/kg BB (84.33) levamisol 2.5 mg/kg BB (93.00), stimuno 9.1 mg/kg BB (91.67). The result showed that on dosage 140 mg/kg BB have imunostimulator effect.
Key words: ethanolic extract of leaf (Sauropus androgynus (L) Merr), phagocytosis macrophage, imunostimulator cream
