: Stroke is a neurological emergency disease caused by sudden disruption of cerebral blood flow which resulted in the death of brain\u27s nerve cells that causing motoric and sensory dysfunction so that ended in disability or death. Range of Motion Exercise is an exercise performed to evaluate and improve the function of the musculoskeletal system and is also one of therapy in stroke patients that aims to increase cerebral blood flow, minimize disability caused by stroke, so as to refine sensory motoric function. Objectives: The objectives of this study is to identify the effects of Range of Motion Exercise to the muscle strength of stroke patients in Neurology Department of General Hospital Prof. R. D. Kandou Manado. Method: This study is a quasi experiment with methods Nonequivalent Control Group Design. The sampling technique that used is purposive sampling. Primary data gain from patient observation sheets and secondary data from the medical records of patients treated at Neurology Department of General Hospital Prof. R. D. Kandou Manado. Sample: this study involving 15 respondents in the research period June 14, 2013 – June 28, 2013 and performed in inpatient room F Neuro BLU RSUP Prof. Dr. R.D. Kandou Manado. Results: the analysis by using a Paired Sample T test statistic-Test wit significance level (α) 0.05, shows scores and muscle strength before and after done the exersice range of motion have elevated the score average of 3.87. Conclusion: the influence of practice range of motion of muscle strength in patients with stroke value of P = 0.003