Poster presented at the 2017 Health Sciences Research Day which was organized and sponsored by the University of Missouri School of Medicine Research Council and held on November 9, 2017.Conclusion: Ang II suppresses autophagy by impairing autophagosome formation, which leads to accumulation of damaged mitochondria and ubiquitinated proteins. Our data strongly suggest that autophagy plays a critical role in Ang II-induced energy imbalance and skeletal muscle wasting, and that it could be a new therapeutic target in wasting disorders such as HF
