Poster apresentado no 4.º Congresso Internacional de Saúde do IP Leiria - “Tendências Globais em Saúde.” 11-12 Maio 2018, LeiriaN/

Auxtero, Maria Deolinda

Costa, Isabel Margarida

Figueiredo, Alexandra

English

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An overview of vitamin B in food supplements Costa I.M.1; Figueiredo, A. 1; Auxtero D.1  1 Instituto Universitário Egas Moniz (IUEM); Centro de Investigação Interdisciplinar Egas Moniz (CiiEM)  Email: isabelc@egasmoniz.edu.pt METHODS CONCLUSIONS AIM RESULTS The aim of this study was to evaluate whether vitamin B (VitB) daily dose indicated on food supplements (FS) labels coincided with the recommended daily allowance (RDA) for this vitamin defined by European Union Directive7 for these vitamins.        Although vitB6 is a co-factor of several enzymatic reactions, long term use of high-doses can lead to adverse health effects 6-7: • Neurological (sensory neuropathy) • Dermatological (photosensitivity, skin rashes) • GI (nausea, vomiting, abdominal pain, loss of appetite)                    • The majority of FS presented vitB far above defined RDA and some above vitB6 UL. • It is crucial that the daily doses present in FS are reviewed ensuring the safety of these products.  Over last decade, sales of vitamins have had a significant increase worldwide. The growth of self-diagnosis and self-medication by consumers and the general misperception that natural products are harmless have contributed to increased consumption of food supplements.  Despite their beneficial effects and being involved in numerous metabolic and physiological processes,  excess intake of vitamins is not innocuous. Although reports of toxic events due to vitamins are scarce, these products are often consumed during extended periods of time, without any control or medical supervision. 1-4    70.0 75.0 67.4 51.1 74.3 45.7 60.3 B1 B2 B3 B5 B6 B7 B12Figure I – % FS with vitB label daily doses above RDA -5.05.015.025.035.045.055.0Label (mg vitB6/day) UL Figure II – 4 FS presented a vitB6 daily dose ≥  tolerable upper intake level defined by EFSA8 (UL=25 mg/day) REFERENCES:  1. Korfali, S. I. et al. Chem. Cent. J. (2013); 2. Smichowski, P. et al. Microchem. J. (2016); 3. Kosalec, I. et al. Arch. Ind. Hyg. Toxicol. (2009); 4. Pillitteri, J. L. et al. Obesity (2008); 5. Commission Directive 2008/100/EC; 6. Hellmann, H. et al. Molecules (2010); 7. Hathcock, J. Vitamin and Mineral Safety (2014); 8. EFSA - Tolerable Upper Intake Levels (2006). Vit RDA Max label (daily dose) B1 1.1 mg 100 mg B2 1.4 mg 50 mg B3 16 mg 100 mg B5 6 mg 100 mg B6 1.4 mg 50 mg B7 50 µg 450 µg B12 2.5 µg 1000 µg Table I – RDA5 for vitB versus maximum FS labeled values INTRODUCTION A total of 80 FS sold in Portuguese pharmacies, supermarkets, health shops and on internet were examined for indicated label daily intake of vitamin B1, B2, B3, B5, B6, B7 and B12 and compared with the respective RDA for each vitamin. Selection criteria included: oral solid pharmaceutical forms for adults, containing vitB in its composition, as stated in the label, regardless of the purpose of the FS.  33 FS With all the studied VitB 6 FS With all VitB above RDA 80 FS Global sample (N) ACKNOWLEDGMENTS: The authors are grateful for the financial support provided for this study by Egas Moniz CRL  

An overview of vitamin B in food supplements

https://comum.rcaap.pt/bitstream/10400.26/29106/1/Poster_IMCosta_2018_03.pdf

An overview of vitamin B in food supplements

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