Antioxidants behave as major defense agents against reactive oxygen species (ROS) which are prominent in many serious illnesses, including
neurodegenerative diseases such as: Alzheimer’s and Parkinson’s diseases [1]. It is thought that some of the symptoms are due to
the imbalance between pro-oxidant and antioxidant homeostasis. Antioxidant defense mechanisms are responsible for the removal of O2,
scavenging of reactive oxygen species or inhibition of reactive oxygen species formation [2]. Therefore the discovery of small molecules
with antioxidant properties is important in the fight against neurodegenerative diseases and microbial infections [2]. In the present study a
small library composed by diazepine and quinolinone derivatives and their precursors (arylamide-acetals) were screened for their antioxidant
and antimicrobial properties. Antioxidant activities were evaluated either by free radical DPPH method and -carotene/linoleic acid system.
The antimicrobial activities were screened against Gram -positive and Gram- negative pathogenic bacteria by disc diffusion assay, and
the minimal inhibitory concentration (MIC) was determined for sensitive strain
