Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European Region to the WHO vaccine composition consultation for northern hemisphere 2017/18

Abstract

European region influenza surveillance Network author lisT - Portugal: Raquel Guiomar, Pedro Pechirra, Paula Cristóvão, Inês Costa, Patricia Conde (National Influenza and Other Respiratory Virus Reference Laboratory, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon) and Ana Paula Rodrigues (Department of Epidemiology, National Instituteof Health Dr. Ricardo Jorge, Lisbon)Erratum in: Erratum to "Predominance of influenza A(H3N2) virus genetic subclade 3C.2a1 during an early 2016/17 influenza season in Europe - Contribution of surveillance data from World Health Organization (WHO) European region to the WHO vaccine composition consultation for northern hemisphere 2017/18" [Vaccine 35 (2017) 4828-4835]. [Vaccine. 2018 May 3;36(19):2740-2741. doi: 10.1016/j.vaccine.2017.12.039. Epub 2017 Dec 20]. Disponível em: https://doi.org/10.1016/j.vaccine.2017.12.039During the European 2016/17 influenza season, A(H3N2) viruses have predominated and the majority clustered in genetic subclade 3C.2a1. Genetic analyses showed that circulating viruses have undergone considerable genetic diversification of the haemagglutinin gene from the current vaccine virus A/Hong Kong/4801/2014 (clade 3C.2a), but the antigenic data that is limited by the challenges with the antigenic characterisation of currently circulating A(H3N2) viruses, showed no clear evidence of antigenic change. The recommended A(H3N2) vaccine component for the northern hemisphere 2017/18 influenza season remained unchanged. However, early and mid-season vaccine effectiveness (VE) estimates were suggestive of reduced VE against A(H3N2) viruses.info:eu-repo/semantics/publishedVersio