Changes in an ontology may have a disruptive impact on any system using it. This impact may depend on structural changes such as introduction or removal of concept definitions, or it may be related to a change in the expected performance of the reasoning tasks. As the number of systems using ontologies is expected to increase, and given the open nature of the Semantic Web, introduction of new ontologies and modifications to existing ones are to be expected. Dynamically handling such changes, without requiring human intervention, becomes crucial. This paper presents a framework that isolates groups of related axioms in an OWL ontology, so that a change in one or more axioms can be automatically localised to a part of the ontology