The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.Title from title screen of research.pdf file (viewed on April 27, 2009)Vita.Thesis (Ph.D.) University of Missouri-Columbia 2006.In vertebrates, brain locomotor command systems activate spinal central pattern generators (CPGs) to initiate locomotor behavior. The size and pharmacology of brain command systems are unknown, and the movements that result from these command systems have not been investigated. In addition, it is uncertain whether reciprocal coupling between right and left spinal locomotor networks is necessary for rhythmogenesis or primarily for phasing of locomotor activity. In the present study, in semi-intact preparations from larval lamprey, stimulation in brain locomotor areas evokes swimming. In in vitro preparations, brain locomotor areas are confined to discrete areas of the brain and their pharmacology is similar to that of other vertebrates. These results suggest that the organization of the lamprey locomotor command system is similar to that in "higher" vertebrates. In separate experiments, results from in vitro preparations and whole animals demonstrated that reciprocal coupling in the spinal cord is necessary for rhythmogenesis.Includes bibliographical reference
