A novel iterative soft interference cancellation (SIC) aided beamforming receiver is developed for high-throughput quadrature amplitude modulation systems. The proposed SIC based minimum symbol error rate (MSER) multiuser detection scheme guarantees the direct and explicit minimization of the symbol error rate at the output of the detector. Adopting the extrinsic information transfer (EXIT) chart technique, we compare the EXIT characteristics of an iterative MSER multiuser detector (MUD) with those of the conventional minimum mean-squared error (MMSE) detector. As expected, the proposed SIC-MSER MUD outperforms the SIC-MMSE MUD. Index Terms—Beamforming, iterative multiuser detection, minimum symbol error rate, quadrature amplitude modulation