The Powhatan Uprising of March 22, 1621/22, was the single most significant event of Anglo-Indian relations in Virginia. An early example of a native culture’s rebellion against intruding European civilization, the uprising climaxed a mere decade and a half of intercultural contact. Its impact upon trans-Atlantic ideology and policy was impressive: it brought to an end the first (forty year) phase of British imperialis [imperialist] accelerated Virginia\u27s unique course of development, and hastened the doom of an American Indian empire with vast potential