CHAU, SL

CHENG, YH

Lok, CN

Ng, KM

Tang, HW

ACS Omega

A chemical printing
method based on gold nanoparticle (AuNP)-assisted
laser ablation has been developed. By rastering a thin layer of AuNPs
coated on a rat kidney tissue section with a UV laser, biomolecules
are extracted and immediately transferred/printed onto a supporting
glass substrate. The integrity of the printed sample is preserved,
as revealed by imaging mass spectrometric analysis. By studying the
mechanism of the extraction/printing process, transiently molten AuNPs
were found to be involved in the process, as supported by the color
and morphological changes of the AuNP thin film. The success of this
molecular printing method was based on the efficient laser–nanomaterial
interaction, that is, the strong photoabsorption, laser-induced heating,
and phase-transition properties of the AuNPs. It is anticipated that
the molecular printing method can be applied to perform site-specific
printing, which extracts and transfers biochemicals from different
regions of biological tissue sections to different types of supporting
materials for subsequent biochemical analysis with the preservation
of the original tissue samples

Siu-Leung Chau (1508923)

Ho-Wai Tang (1508926)

Yu-Hong Cheng (3236520)

Chun-Nam Lok (2308549)

Kwan-Ming Ng (1508917)

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Chemical Printing of Biological Tissue by Gold Nanoparticle-Assisted
Laser Ablation

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Chemical Printing of Biological Tissue by Gold Nanoparticle-Assisted Laser Ablation

Chemical Printing of Biological Tissue by Gold Nanoparticle-Assisted Laser Ablation

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