Cai, J

Huang, J

Kao, RYT

Lin, Q

Sze, KH

Xiong, L

XU, C

Yang, X

Yu, B

Yuen, KY

ZHANG, B

Zheng, S

The Journal of Infectious Diseases

Bao-Zhong Zhang

JianPiao Cai

Bin Yu

Lifeng Xiong

Qiubin Lin

Xiao-Yan Yang

Chen Xu

SongYue Zheng

Richard Yi-Tsun Kao

Konghung Sze

Kwok-Yung Yuen

Jian-Dong Huang

Crossref

Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model

Staphylococcusaureus is a severe pathogen found in the community and in hospitals. Most notably, methicillin-resistant S. aureus (MRSA) is resistant to almost all antibiotics, which is a growing public health concern. The emergence of drug-resistant strains has prompted the search for alternative treatments such as immunotherapeutic approaches. Previous research showed that S. aureus exploit the immunomodulatory attributes of adenosine to escape host immunity. In this study, we investigated adenosine synthase A (AdsA), an S. aureus cell wall-anchored enzyme as possible targets for immunotherapy. Mice vaccinated with aluminum hydroxide-formulated recombinant AdsA (rAdsA) induced high-titer anti-AdsA antibodies, thereby providing consistent protection in 3 mouse infection models when challenged with 2 S. aureus strains. The importance of anti-AdsA antibody in protection was demonstrated by passive transfer experiments. Moreover, AdsA-specific antisera promote killing S. aureus by immune cells. Altogether, our data demonstrate that the AdsA is a promising target for vaccines and therapeutics development to alleviate severe S. aureus diseases.published_or_final_versio

Zhang, B

Xu, C

HKU Scholars Hub

http://hub.hku.hk/bitstream/10722/246929/1/content.pdf

Immunotherapy Targeting Adenosine Synthase A Decreases Severity of Staphylococcus aureus Infection in Mouse Model

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HKU Scholars Hub