Instituto Nacional de Saúde Doutor Ricardo Jorge, IP
Abstract
AIM: To study the polymorphic variants in CYP2C9*2*3 and the C-174G promoter polymorphism of the IL-6 gene on Infertile Women.BACKGROUND: - Infertility affects 15–20% of couples worldwide. Within the past decades, there has been a steady rise in the treatment of female infertility with several drugs; - The cytochrome P450 (CYP) genes are oxygenases involved in estrogen biosynthesis and metabolism, generation of DNA damaging procarcinogens, and response to anti-estrogen therapies used in female infertility treatments: - Interleukin-6 (IL-6) is a pleiotropic proinflammatory cytokine, highly expressed in the female urogenital tract and reproductive organs. It has been implicated in estrogen metabolism imbalance.N/
