We present the computational framework MATRIX which allows us to evaluate
fully differential cross sections for a wide class of processes at hadron
colliders in next-to-next-to-leading order (NNLO) QCD. The processes we
consider are 2→1 and 2→2 hadronic reactions involving Higgs and
vector bosons in the final state. All possible leptonic decay channels of the
vector bosons are included for the first time in the calculations, by
consistently accounting for all resonant and non-resonant diagrams, off-shell
effects and spin correlations. We briefly introduce the theoretical framework
MATRIX is based on, discuss its relevant features and provide a detailed
description of how to use MATRIX to obtain NNLO accurate results for the
various processes. We report reference predictions for inclusive and fiducial
cross sections of all the physics processes considered here and discuss their
corresponding uncertainties. MATRIX features an automatic extrapolation
procedure that allows us, for the first time, to control the systematic
uncertainties inherent to the applied NNLO subtraction procedure down to the
few permille level (or better).Comment: 76 pages, 2 figures, 11 table