The Mycobacterium tuberculosis (M. tuberculosis)-
speciWc culture Wltrate protein-10 (CFP-10) is highly
recognized by M. tuberculosis infected subjects. In the
present study, the proliferative response and IFN-� secretion
was found for C-terminal peptides of the protein
(Cfp651–70, Cfp761–80, Cfp871–90, and Cfp981–100). The alleles
HLA DRB1 *04 and HLA DRB1 *10 recognized the
C-terminal peptides Cfp7, Cfp8, and Cfp9 in HHC. Cfp6
was predominantly recognized by the alleles HLA DRB1
*03 and HLA DRB1 *15 by PTB. The minimal nonameric
epitopes from the C-terminal region were CFP-1056–64 and
CFP-1076–84. These two peptides deserve attention for
inclusion in a vaccine against tuberculosis in this region