Chem Clin Biochem

Davide Gatti

Eur J Clin

Giorgio Brocco

Maurizio Rossini

Nicoletta Zamberlan

Romolo Dorizzi

Silvano Adami

Vania Braga

Clinical Chemistry and Laboratory Medicine (CCLM)

Undetermined

Braga, Vania

Dorizzi, Romolo

Brocco, Giorgio

Rossini, Maurizio

Zamberlan, Nicoletta

Gatti, Davide

Adami, Silvano

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Clinical Utility of a Wheat-Germ Precipitation Assay for Determination of Bone Alkaline Phosphatase Concentrations in Patients with Different Metabolic Bone Diseases

Summary: Bone alkaline phosphatase was evaluated by wheat-germ lectin precipitation in several clinical condi-tions. The study included 33 premenopausal healthy women, 46 postmenopausal apparently healthy women, 19 growing children, 24 patients with Pagefs disease, 31 patients with primary hyperparathyroidism and 66 patients with hepatobiliary diseases. In postmenopausal women the mean T score (i. e.: the number of SD below or above the mean for premenopausal women) was 2.6 ± 1.3 (SD) for bone alkaline phosphatase and 1.61 ± 1.21 for total alkaline phosphatase (p &lt; 0.001). The T score for bone alkaline phosphatase provided a better discrimination from normals for both Pagefs disease (22.1 ± 27.8 versus 12.8 ± 16 p &lt; 0.001) and primary hyperparathyroidism (8.2 ± 4.3 versus 4.6 ± 3.7 p &lt; 0.005 for bone alkaline phosphatase and total alkaline phosphatase respectively). After treatment with intravenous bisphosphonate the percent decrease of bone alkaline phosphatase was larger than that of total alkaline phosphatase both in patients with Pagefs disease (-46 % versus-72 % p &lt; 0.01) and in patients with primary hyperparathyroidism (—21 % versus —47 % p &lt; 0.02) and an estimate of the precision (Δ mean/SD of the Δ mean) for bone alkaline phosphatase was 1.9—3.7 times higher than that of total alkaline phosphatase. In twelve osteoporotic patients treated for six months with oral alendronate the decrease in bone turnover was detected with significantly higher precision with bone alkaline phosphatase than with total alkalin

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V. Braga

R. Dorizzi

G. Brocco

N. Zamberlan

ROSSINI, Maurizio

GATTI, Davide

ADAMI, Silvano

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Clinical utility of a wheat-germ precipitation assay for determination of bone alkaline phosphatase concentrations in patients with different metabolic bone diseases.

Bone alkaline phosphatase was evaluated by wheat-germ lectin precipitation in several clinical conditions. The study included 33 premenopausal healthy women, 46 postmenopausal apparently healthy women, 19 growing children, 24 patients with Paget's disease, 31 patients with primary hyperparathyroidism and 66 patients with hepatobiliary diseases. In postmenopausal women the mean T score (i.e.: the number of SD below or above the mean for premenopausal women) was 2.6 +/- 1.3 (SD) for bone alkaline phosphatase and 1.61 +/- 1.21 for total alkaline phosphatase (p < 0.001). The T score for bone alkaline phosphatase provided a better discrimination from normals for both Paget's disease (22.1 +/- 27.8 versus 12.8 +/- 16 p < 0.001) and primary hyperparathyroidism (8.2 +/- 4.3 versus 4.6 +/- 3.7 p < 0.005 for bone alkaline phosphatase and total alkaline phosphatase respectively). After treatment with intravenous bisphosphonate the percent decrease of bone alkaline phosphatase was larger than that of total alkaline phosphatase both in patients with Paget's disease (-46% versus -72% p < 0.01) and in patients with primary hyperparathyroidism (-21% versus -47% p < 0.02) and an estimate of the precision (delta mean/SD of the delta mean) for bone alkaline phosphatase was 1.9-3.7 times higher than that of total alkaline phosphatase. In twelve osteoporotic patients treated for six months with oral alendronate the decrease in bone turnover was detected with significantly higher precision with bone alkaline phosphatase than with total alkaline phosphatase (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS

Clinical utility of a wheat-germ precipitation assay for determination of bone alkaline phosphatase concentrations in patients with different metabolic bone diseases

https://edoc.hu-berlin.de/bitstream/18452/13673/1/cclm.1995.33.7.433.pdf

Clinical Utility of a Wheat-Germ Precipitation Assay for Determination of Bone Alkaline Phosphatase Concentrations in Patients with Different Metabolic Bone Diseases

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