Correlation Between Demographics, Clinical and Risk Factor for HIV Infection with HIV/TB Coinfected in Amertha Clinic Kerti Praja Foundation Denpasar

Abstract

Background and purpose: HIV infection increases the risk of developing tuberculosis (TB), as TB infection increases the progression of HIV. In Bali, HIV/TB coinfected patients have increased from 26% in 2012 to 30% in 2013. Study on factors related with the occurrence of HIV/TB coinfection is limited in Indonesia. This study aims to determine the correlation between demographics, clinical and risk factor for HIV infected with HIV/TB coinfected in Amertha Clinic Kerti Praja Foundation Bali.Methods: The study design was cross-sectional using secondary data of patients with HIV/AIDS who were receiving antiretroviral therapy (ART) from 2002-2012. Independent variables were demographics: gender, age, education level, working status, and presence of ART supervisor; clinical: haemoglobin count, weight, CD4 count; and risk factor for HIVinfected. The status of HIV/TB coinfection was the dependent variable. Data was analysed using univariate, bivariate (chi-square) and multivariate (cox regression).Results: From the 531 patients, the majority were male (57,6%) and aged ?31 years (50,8%). 5,5% of patients experienced HIV/TB coinfection. Multivariate analysis indicated that the variables correlating with HIV/TB coinfection occurence were CD4 count at baseline ?200 cell/mm3 (PR=10,34; 95%CI: 1,39-76,69;p=0,022) and risk factor for HIV infected with IDU (PR=3,27; 95%CI: 1,56-6,88;p=0,002).Conclusion: Patients with CD4 count ?200 cell/mm3 and HIV infected by IDU have correlating with HIV/TB coinfection