Uji Efek Analgesik Ekstrak Daun Pepaya (Carica Pepaya (L.)) Pada Mencit (Mus Musculus)

Abstract

Background : The natural medicine has been known and used throughout of the world for thousands of the years. One of them is papaya. efficacy papaya leave provide efficacy as fever, appetite enhancer, launsed menstruation and relieve pain. This study aims to determine whether the extract of papaya leaves have analgesic effects on mice by using the method of thermal stimulation.Methods : This study is an experimental study using nine mice. This animals were divided into three groups where each group consisting of three mice. Papaya leaves, tramadol, and aquades were give to each group as test substances and comparative solution. Observations were carried out for 1 minute using the method of thermal stimulation was a decreases of protection mechanism of the mice in of licking and or flicking responses after the administration of test substances.Results : There was a decrease of the response of mice to lick feet and or jump to the heat stimuli were given after administration of papaya leaf extract.Conclusion : The extract of papaya leaves has an analgesic effect on mice