Hubungan Antara Ekspresi Ki-67 Dan Kaspase-3 Dengan Respons Kemoterapi Neoajuvan Pada Pasien Karsinoma Serviks Stadium IB2 Dan IIA2 Di Rumah Sakit Dr. Hasan Sadikin, Bandung

Abstract

Cervical carcinoma is the second ranks cancer in women in developing countries. This study was a retrospective cohortstudy of the relationship between the role of Ki-67 expression and caspase-3 on tumor shrinkage response in cervical carcinoma stage IB2 and IIA2. A total of 41 cases have been done NACT with Cisplatin, Vincristine and Bleomycin. All samples showed expression in immunohistochemical staining for Ki-67 and caspase-3. Meanwhile, Pearson correlation analysis found no correlation between the expression levels of Ki-67 and caspase-3 with a diminution oftumor mass (p>0.05). While the correlation between the ratio of Ki-67 expression and caspase-3 with a significant diminution of tumor mass is obtained p 0.042, R-0.319, means that the higher the Ki-67 expression levels compared caspase-3 expression level then the response of the tumor mass size reduction will be better