Bland, R.M.

Houle, B.

Newell, M.L.

Pearson, R.M.

Rochat, T.J.

Stein, A.

International Journal of Epidemiology

English

Each year millions of children in low- and middle-income countries (LMIC) fail to reach their developmental potentialdue to factors including poverty, malnutrition, poor stimulation and HIV. Although vertically-acquired HIV can now be prevented, little is known about the impact of HIV exposure in fetal and early life on the development of the many HIVnegative children. The Siyakhula Cohort was established within the Canadian Grand Challenges ‘Saving Brains’ initiative, to support re-enrolment of strategic cohorts in LMIC. This unique cohort in rural South Africa includes 1536 HIVnegative children born to HIV-infected (HIV-exposed) and HIV-uninfected (unexposed) mothers, enrolled from the Africa Health Research Institute (AHRI)–formerly the Africa Centre for Population Health (Africa Centre). The cohort includes data on HIV exposure in fetal and early life, and other early life factors (including breastfeeding) known to impact on later health outcomes. At birth, all children benefited from the early Prevention of Mother-to-Child-Transmission of HIV services in the district, and a subgroup were part of an additional early life breastfeeding intervention, the Vertical Transmission Study (VTS). This cohort pre-dated antiretroviral treatment (ART) roll-out, allowing for examination of outcomes associated with HIV exposure without ART exposure in utero and during breastfeeding. Current assessments at ages 7–11 years collected data on growth, health, cognition (including executive function), education and emotional-behavioural outcomes at primary school age

Rochat, TJ

Houle, B

Stein, A

Pearson, RM

Newell, ML

Bland, RM

Oxford University Research Archive (ORA)

Cohort Profile: Siyakhula Cohort, rural South Africa

Each year millions of children in low- and middle-income countries (LMIC) fail to reach their developmental potential due to factors including poverty, malnutrition, poor stimulation and HIV. Although vertically-acquired HIV can now be prevented, little is known about the impact of HIV exposure in fetal and early life on the development of the many HIV-negative children. The Siyakhula Cohort was established within the Canadian Grand Challenges ‘Saving Brains’ initiative, to support re-enrolment of strategic cohorts in LMIC. This unique cohort in rural South Africa includes 1536 HIV-negative children born to HIV-infected (HIV-exposed) and HIV-uninfected (unexposed) mothers, enrolled from the Africa Health Research Institute (AHRI)–formerly the Africa Centre for Population Health (Africa Centre). The cohort includes data on HIV exposure in fetal and early life, and other early life factors (including breastfeeding) known to impact on later health outcomes. At birth, all children benefited from the early Prevention of Mother-to-Child-Transmission of HIV services in the district, and a subgroup were part of an additional early life breastfeeding intervention, the Vertical Transmission Study (VTS). This cohort pre-dated antiretroviral treatment (ART) roll-out, allowing for examination of outcomes associated with HIV exposure without ART exposure in utero and during breastfeeding. Current assessments at ages 7–11 years collected data on growth, health, cognition (including executive function), education and emotional-behavioural outcomes at primary school age

Rochat, T J

Pearson, R M

Newell, M L

Bland, R M

Explore Bristol Research

Cohort Profile:The Siyakhula Cohort, rural South Africa

T J Rochat

B Houle

A Stein

R M Pearson

M L Newell

R M Bland

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Cohort Profile: The Siyakhula Cohort, rural South Africa

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Cohort profile: the Siyakhula cohort, rural South Africa

Stein, Alan

Oxford University Research Archive

First published online: 21 August 2017, Int J Epidemiol 2017; 46(6):1755–1756n. DOI: https://doi.org/10.1093/ije/dyx148.In Figure 3, in both Model 1 and Model 2, the second and third boxes on the left were incorrectly labelled. They should read KABC Planning Index rather than KABC Learning Index

                          Rochat, T. J., Houle, B., Stein, A., Pearson, R. M., Newell, M. L., & Bland,R. M. (2018). [Correction to] Cohort Profile: The Siyakhula Cohort, ruralSouth Africa. International Journal of Epidemiology, 47(2), 680. [dyy009].https://doi.org/10.1093/ije/dyy009Publisher's PDF, also known as Version of recordLicense (if available):CC BYLink to published version (if available):10.1093/ije/dyy009Link to publication record in Explore Bristol ResearchPDF-documentThis is the final published version of the article (version of record). It first appeared online via Oxford UniversityPress at https://academic.oup.com/ije/article/47/2/680/4822280 . Please refer to any applicable terms of use ofthe publisher.University of Bristol - Explore Bristol ResearchGeneral rightsThis document is made available in accordance with publisher policies. Please cite only the publishedversion using the reference above. Full terms of use are available:http://www.bristol.ac.uk/pure/about/ebr-termsCorrigendumCohort Profile: The Siyakhula Cohort, ruralSouth AfricaTJ Rochat, B Houle, A Stein, RM Pearson, ML Newell, RM BlandFirst published online: 21 August 2017, Int J Epidemiol 2017; 46(6):1755–1756n.DOI: https://doi.org/10.1093/ije/dyx148.In Figure 3, in both Model 1 and Model 2, the second andthird boxes on the left were incorrectly labelled. Theyshould read KABC Planning Index rather than KABCLearning Index.VC The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. 680This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permitsunrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.International Journal of Epidemiology, 2018, 680doi: 10.1093/ije/dyy009Advance Access Publication Date: 23 January 2018CorrigendumDownloaded from https://academic.oup.com/ije/article-abstract/47/2/680/4822280 by University of Bristol Library user on 06 September 2018

[Correction to] Cohort Profile:The Siyakhula Cohort, rural South Africa

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Cohort profile: the Siyakhula cohort, rural South Africa

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