The toxicological assessment of 17 GSCs returned aboard Soyuz 28 and 29 from the ISS is shown in Table 1. The average recoveries of the 3 surrogate standards from the GSCs were as follows: (C-13)-acetone, 110%; fluorobenzene, 107%; and chlorobenzene, 99%. Recoveries from formaldehyde badges, which were returned on 29S, averaged 101%

James, John T.

NASA Technical Reports Server

  
                                                                                                                                                    
The toxicological assessment of 17 GSCs returned aboard Soyuz 28 and 29 from the ISS is shown in Table 1. The average 
recoveries of the 3 surrogate standards from the GSCs were as follows: 13C-acetone, 110%; fluorobenzene, 107%; and 
chlorobenzene, 99%. Recoveries from formaldehyde badges, which were returned on 29S, averaged 101%. 
 
Table 1. Analytical Summary of ISS Results   
Module/Sample Date of 
Sample 
NMVOCsa
  (mg/m3) 
Freon 218 
(mg/m3) 
T Valueb
 (units) 
Alcohols 
  (mg/m3) 
Formaldehyde 
    (µg/m3) 
Lab 12/23/11 9 32 0.40 5.9 42 
JPM 12/23/11 10 35 0.39 6.2 -- 
SM 12/23/11 9 33 0.36 5.8 35 
COL 01/09/12 10 11 0.76 6.6 -- 
Lab 01/09/12 11 35 0.50 7.2 55 
SM 01/09/12 -- -- -- -- 41 
Lab  02/01/12 8 36 0.78 5.0 50 
JPM 02/01/12 9 23 0.74 5.7 -- 
SM 02/01/12 -- -- -- -- 37 
Lab 02/27/12 7 16 0.66 4.6 34 
COL 02/27/12 8 17 0.50 5.0 -- 
SM 02/27/12 9 20 1.02 5.9 38 
ATV3 (first entry) 03/29/12 28 2 2.64 (0.94) 5.9 -- 
Lab  04/03/12 8 15 0.68 4.6 37 
JPM 04/03/12 9 18 0.75 5.0 -- 
SM 04/03/12 8 28 0.72 4.8 27 
SM 04/24/12 8 31 0.43 5.1 -- 
Lab 04/24/12 8 30 0.50 4.6 -- 
Lab 05/29/12 16 31 0.42 6.8 33 
SM 05/29/12 -- -- -- -- 32 
Guideline  <25 none <1.0 <5 <120
a Non-methane volatile organic hydrocarbons, excluding Freon 218 
bBased on 180-d SMACs and calculated excluding CO2 and formaldehyde. Parentheses indicate 7-day SMAC comparison. 
 
General Observations about ISS Air Quality: This is a very limited set of samples on which to perform an air 
quality assessment. However, based on these samples, we have no reason to believe that nominal ISS air is 
unsafe to breathe. Formaldehyde values were up some in January and early February, but were decreased to ~30 
μg/m3 by late February. The relatively high T value at ATV3 first entry was due to the presence of 
hexamethylcyclotrisiloxane, trimethylsilanol, and fluorotrimethylsilane, all compounds that are reasonably well 
removed by the air revitalization systems.    
Air Quality Monitor DTO: The figures below summarize the potential for any health effects based on data from 
the Air Quality Monitor (AQM) DTO, CO2 monitors, and formaldehyde badges. Each panel is an average of 
weekly panels created during the designated month with the SD of those values shown as limit bars. By 
remaining consistently below T=1, these data show that the air quality is nominal and stable. 
Toxicological Assessment of ISS Air Quality: 
December 2011 to May 2012 
https://ntrs.nasa.gov/search.jsp?R=20120014180 2019-08-30T21:58:04+00:00Z
  
 
 
 
----------------------------------------- 
John T. James, Ph.D., Chief Toxicologist 
 
Enclosures Table 1: Analytical concentrations of compounds found in the Soyuz 28&29 GSCs 
Table 2: T-values of the compounds in table 1 
0 1
Cardiac sensitization
Mucosal irritant…
Carcinogen (any type)
CNS depression
Nephrotoxic
Reproductive toxicant
Respiratory system injury
Hematotoxicant
Immunotoxicant
Ototoxicant
Visual disturbances
Hepatotoxicant
Skin flushing
Urinary bladder injury
Gastrointestinal toxicity
Headache
No listed Effect
January  2012
0 1
Cardiac sensitization
Mucosal irritant…
Carcinogen (any type)
CNS depression
Nephrotoxic
Reproductive toxicant
Respiratory system injury
Hematotoxicant
Immunotoxicant
Ototoxicant
Visual disturbances
Hepatotoxicant
Skin flushing
Urinary bladder injury
Gastrointestinal toxicity
Headache
No listed Effect
February 2012
0 1
Cardiac sensitization
Mucosal irritant…
Carcinogen (any type)
CNS depression
Nephrotoxic
Reproductive toxicant
Respiratory system injury
Hematotoxicant
Immunotoxicant
Ototoxicant
Visual disturbances
Hepatotoxicant
Skin flushing
Urinary bladder injury
Gastrointestinal toxicity
Headache
No listed Effect
March 2012
0 1
Cardiac sensitization
Mucosal irritant…
Carcinogen (any type)
CNS depression
Nephrotoxic
Reproductive toxicant
Respiratory system injury
Hematotoxicant
Immunotoxicant
Ototoxicant
Visual disturbances
Hepatotoxicant
Skin flushing
Urinary bladder injury
Gastrointestinal toxicity
Headache
No listed Effect
April  2012 


Toxicological Assessment of ISS Air Quality: December 2011 to May 2012

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