Bone loss represents one of the most significant effects of space flight on the human body. Understanding the mechanisms underlying this loss is critical for maintaining crew health and safety during and after flight. This investigation documents the changes in bone metabolism and calcium kinetics during and after space flight. We previously reported calcium studies on three subjects during and after a 115-d stay on the Russian space station Mir. We report here data on an additional three subjects, whose stays on Mir were approximately 4 (n=l) and 6 (n=2) mos. Previously published data are included for comparison
