This review examines research on mentoring American Indian and Alaska Native (AI/AN) youth. The review is organized around four questions: 1. What is the effectiveness of mentoring for American Indian and Alaska Native youth? 2. What factors influence the effectiveness of mentoring for American Indian and Alaska Native youth? 3. What pathways are most important in linking mentoring to outcomes for American Indian and Alaska Native youth? 4. To what extent have mentoring initiatives for American Indian and Alaska Native youth reached and engaged the youth, been implemented with high quality, and been adopted and sustained