The development of new classifications of inhibitors is essential in order to control infectious diseases. Currently the only antibiotics available follow two approaches: inhibition of cell wall remodeling and protein synthesis. DapE is part of the succinylase biosynthetic pathway and is important to the production of lysine and mDap both of which synthesize protein and bacterial peptidoglycan cell wall remodeling. There is no evidence of DapE in mammals, therefore, inhibition should be essential in antibiotic development