JEM-EUSO space observatory is planned with a very large exposure factor which will exceed the critical exposure factor required for observing the most of the sources within the propagational horizon of about one hundred Mpc. The main science objective of JEM-EUSO is the source-identifying astronomy in particle channel with extremey-high-energy particles. Quasi-linear tracking of the source objects through galactic magnetic field should become feasible at energy > 10(exp 20) eV for all-sky. The individual GZK profile in high statistics experiments should differ from source to source due to different distance unless Lorentz invariance is somehow limited. hi addition, JEM-EUSO has three exploratory test observations: (i), extremely high energy neutrinos beginning at E > 10(exp 19) eV: neutrinos as being expected to have a slowly increasing cross section in the Standard Model, and in particular, hundreds of times more in the extra-dimension models. (ii). fundamental physics at extreme Super LHC (Large Hadronic Collider) energies with the hierarchical unified energy much below the GUT scale, and (iii). global atmospheric observation, including large-scale and local plasma discharges, night-glow, meteorites, and others.