High-resolution multispectral data are becoming widely available for commercial and scientific use. For specific applications, such as agriculture studies, there is a need to quantify the performance of such systems. In many cases, parameters such as GSD and SNR can be optimized. Data sets with varying GSD's for the Landsat ETM+ bands were produced to evaluate the effects of GSD on various algorithms and transformations, such as NDVI, principal component analysis, unsupervised classification, and mixture analysis. By showing that AVIRIS data can be used to simulate spaceborne and airborne multispectral platforms over a wide range of GSD, this research can be used to assist in band selection and spatial resolution specifications for new sensors and in optimization of acquisition strategies for existing multispectral systems