Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.We gratefully acknowledge funding from the British Council, UK and DST-Inspire, India (Newton-Bhabha Ph.D Placement Programme, SSM) and the Engineering and Physical Sciences Research Council (grants EP/K009494/1 and EP/K039520/1)
